Action Package Prevent-3 Biosafety and Biosecurity (APP3)

The Global Health Security Agenda (GHSA) Action Package Prevent-3 Biosafety and Biosecurity (APP3) aims to advance global biosafety and biosecurity, in support of international instruments and agreements, including the International Health Regulations (IHR) (2005), the Biological and Toxin Weapons Convention (BTWC) (1975), and United Nations Security Council Resolution 1540 (2004). APP3 maintains that strong, whole-of-society biosafety and biosecurity systems enable countries to protect populations and counter biological threats, regardless of origin – natural, accidental, or intentional – while also fostering scientific progress and improving health security through international collaboration.

Biological events, when not met with adequate levels of prevention and preparedness, can have significant public health, social, and financial consequences. The expansion of infrastructure and resources dedicated to working with biological agents and living systems increases the need to ensure proper biosafety and biosecurity to protect researchers and the community. The risk of a catastrophic biological event continues to be magnified by global travel, urbanization, terrorist interest in weapons of mass destruction, and rapid advances in technology that may result facilitate the creation or manipulation of pathogens with pandemic potential. This also includes addressing emerging risks associated with advances in technology as they relate to dual use research.

This Action Package seeks to advance global biosafety and biosecurity, in support of various international instruments and agreements, including IHR, the Biological Weapons Convention, and UNSCR 1540.

  • Promote full compliance with biosafety and biosecurity targets as outlined in the Biosafety and Biosecurity Action Package and the indicators from the World Health Organization’s Joint External Evaluation (JEE) tool, the World Organization for Animal Health Performance of Veterinary Service Pathway, through active participation in relevant fora, membership growth, and regular dialogue.
  • Track actions and progress to achieve the biosafety and biosecurity targets of the GHSA and indicators of the WHO JEE tool and/or OIE PVS, by collaborating with NTI on the Global Biosecurity Dialogue across three major action areas (policy frameworks, capability development, and emerging biological risks).
  • Act as a liaison between donors and recipients, pairing committed countries looking for support to donor countries seeking to direct resources towards effective capacity building. This could be done by partnering with ongoing efforts within the Global Partnership Against the Spread of Weapons and Materials of Mass Destruction (GP) Biosecurity Working Group (BSWG) and will incorporate recommendations from the NTI Global Biosecurity Dialogue.

2023 APP3 Workplan Strategic Objectives:

1) Encouraging military-civilian engagement/collaboration to improve biosafety/biosecurity

2) Increase awareness of—and incentivize actions to reduce—biosecurity and biosafety risks posed by emerging and advanced technologies

3) Enhancing Global South engagement in biosafety/biosecurity events and engagements, and increasing South-South collaboration

Visit the 2023 APP3 Workplan for more on these strategic objectives.

Contributing Members



“We learn how specific actions have enhanced Biosafety & Biosecurity in other countries. Consequently, we become aware of our own gaps, the guide towards improvement and the urgency needed. APP3 is a community for shared learning and awakening for action.”

Anthony Ahumibe
Nigeria Centre For Disease Control

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